Publications

29. Lily Watkins, Saikat Mukherjee, and Jeffrey Tithof. "Dynamics of waste proteins in brain tissue: numerical insights into Alzheimer’s risk factors." Submitted.

28. Rashad Hussain, Jeffrey Tithof, Wei Wang, Arokoruba Cheetham-West, Wei Song, Weiguo Peng, Björn Sigurdsson, Daehyun Kim, Qian Sun, Sisi Peng, Virginia Plá, Douglas H. Kelley, Hajime Hirase, Jorge A. Castorena-Gonzalez, Steven A. Goldman, Pia Weikop, Michael J. Davis, and Maiken Nedergaard. "Potentiating glymphatic-lymphatic drainage abrogates post-traumatic cerebral edema." Nature (2023). [Link]

27. Daehyun Kim, Yiming Gan, Maiken Nedergaard, Douglas H. Kelley, and Jeffrey Tithof. "Image Analysis Techniques for In Vivo Quantification of Cerebrospinal Fluid Flow." Exp. Fluids 64.11 (2023): 181. [Link]

26. Jeffrey Tithof, Timothy L. Pruett, and Joseph Sushil Rao. "Lumped parameter liver simulation to predict acute hemodynamic alterations following partial resections." J. Roy. Soc. Interface 20.207 (2023): 20230444. [Link]

25. Saikat Mukherjee, Mahsa Mirzaee, and Jeffrey Tithof. "Quantifying the relationship between spreading depolarization and perivascular cerebrospinal fluid flow." Sci. Rep. 13 (2023): 12405. [Link]

24. Tomas Bohr, Poul G. Hjorth, Sebastian C. Holst, Sabina Hrabetova, Vesa Kiviniemi, Tuomas Lilius, Iben Lundgaard, Kent-Andre Mardal, Erik A. Martens, Yuki Mori, Valentin Nagerl, Charles Nicholson, Allen Tannenbaum, John H. Thomas, Jeffrey Tithof, Helene Benveniste, Jeffrey J. Iliff, Douglas H. Kelley, and Maiken Nedergaard. "The glymphatic system: Current understanding and modeling." iScience 25 (2022): 104987. [Link]

23. Jung-Shen B. Tai, Saikat Mukherjee, Thomas Nero, Rich Olson, Jeffrey Tithof, Carey D. Nadell, and Jing Yan. "Social evolution of shared biofilm matrix components." P. Natl. Acad. Sci. 119.27 (2022): e2123469119. [Link]

22. Kimberly A. S. Boster, Jeffrey Tithof, Douglas D. Cook, John H. Thomas, and Douglas H. Kelley. "Sensitivity analysis on a network model of glymphatic flow." J. Roy. Soc. Interface 19.191 (2022): 20220257. [Link]

21. Jeffrey Tithof, Kimberly A. S. Boster, Peter A. R. Bork, Maiken Nedergaard, John H. Thomas, and Douglas H. Kelley. "A network model of glymphatic flow under different experimentally-motivated parametric scenarios." iScience 25 (2022): 104258. [Link]

20. Saikat Mukherjee and Jeffrey Tithof. "Model of glymphatic clearance of aggregating proteins from the brain interstitium." Phys. Rev. E 105.2 (2022): 024405. [Link]

19. Ting Du, Humberto Mestre, Benjamin T. Kress, Guojun Liu, Amanda M. Sweeney, Andrew J. Samson, Martin Kaag Rasmussen, Kristian Nygaard Mortensen, Peter A. R. Bork, Weiguo Peng, Genaro E. Olveda, Logan Bashford, Edna R. Toro, Jeffrey Tithof, Douglas H. Kelley, John H. Thomas, Poul G. Hjorth, Erik A. Martens, Rupal I. Mehta, Hajime Hirase, Yuki Mori, and Maiken Nedergaard. "Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema." Brain (2021): awab293. [Link]

18. Aditya Raghunandan, Antonio Ladrón-de-Guevara, Jeffrey Tithof, Humberto Mestre, John H. Thomas, Maiken Nedergaard, and Douglas H. Kelley. "Bulk flow of cerebrospinal fluid observed in periarterial spaces is not an artifact of injection." eLife 10 (2021): e65958. [Link]

17. Daniel E. Troyetsky, Jeffrey Tithof, John H. Thomas, and Douglas H. Kelley. "Dispersion as a waste-clearance mechanism in flow through penetrating perivascular spaces in the brain." Sci. Rep. 11 (2021): 4595. [Link

16. Fatima Min Rivas, Jia Liu, Benjamin C. Martell, Ting Du, Humberto Mestre, Maiken Nedergaard, Jeffrey Tithof, John H. Thomas, and Douglas H. Kelley. "Surface periarterial spaces in the mouse brain are open, not porous." J. Roy. Soc. Interface 15 (2020): 0593. [Link]

15. Alec T. Salminen, Jeffrey Tithof, Yara Izhiman, Elysia A. Masters, Molly C. McCloskey, Thomas R. Gaborski, Douglas H. Kelley, Anthony P. Pietropaoli, Richard E. Waugh, and James L. McGrath. "Endothelial cell apicobasal polarity coordinates distinct responses to luminally versus abluminally delivered TNF-α in a microvascular mimetic." Integr. Biol. 12 (2020): zyaa022. [Link] [Movie 1, Movie 2, Movie 3, Movie 4, Movie 5, Movie 6]

14. Humberto Mestre, Ting Du, Amanda M. Sweeney, Guojun Liu, Andrew J. Samson, Weiguo Peng, Kristian Nygaard Mortensen, Frederik Filip Stæger, Peter A. R. Bork, Logan Bashford, Edna R. Toro, Jeffrey Tithof, Douglas H. Kelley, Poul G. Hjorth, Erik A. Martens, Rupal I. Mehta, Orestes Solis, Pablo Blinder, David Kleinfeld, Hajime Hirase, Yuki Mori, Maiken Nedergaard. "Cerebrospinal fluid influx drives acute ischemic tissue swelling." Science 367 (2020). [Link]

13. Jeffrey Tithof, Douglas H. Kelley, Humberto Mestre, Maiken Nedergaard, and John H. Thomas. "Hydraulic resistance of periarterial spaces in the brain." Fluids Barriers CNS 16 (2019): 19. [Link]

12. Benjamin C. Martell, Jeffrey Tithof, and Douglas H. Kelley. "Comparing free surface and interface motion in electromagnetically driven thin-layer flows." Phys. Rev. Fluids. 4 (2019): 043904. [Link]

11. Humberto Mestre*, Jeffrey Tithof*, Ting Du, Wei Song, Weiguo Peng, Amanda M. Sweeney, Genaro Olveda, John H. Thomas, Maiken Nedergaard, and Douglas H. Kelley. "Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension." Nature Commun 9 (2018): 1–9. *Denotes equal contribution. [Link] [Movie 1, Movie 2, Movie 3, Movie 4]

10. Benjamin A. Plog, Humberto Mestre, Genaro Olveda, H. Mark Kenney, Alexander Cove, Kosha Y. Dholakia, Jeffrey Tithof, Thomas D. Nevins, Iben Lundgaard, Ting Du, Douglas H. Kelley, and Maiken Nedergaard. "Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain." JCI Insight 3 (2018): e120922. [Link] [Movie 1, Movie 2, Movie 3, Movie 4]

9. Balachandra Suri, Jeffrey Tithof, Roman O. Grigoriev, and Michael F. Schatz. "Unstable equilibria and invariant manifolds in a quasi-two-dimensional Kolmogorov-like flow." Phys. Rev. E 98 (2018): 023105. [Link]

8. Jeffrey Tithof, Benjamin C. Martell, and Douglas H. Kelley. "Three-dimensionality of one- and two-layer electromagnetically driven thin-layer flows." Phys. Rev. Fluids 3 (2018): 064602. [Link]

7. Jinge Wang, Jeffrey Tithof, Thomas D. Nevins, Rony O. Colón, and Douglas H. Kelley. "Optimal stretching in the reacting wake of a bluff body." Chaos 27 (2017): 123109. [Link]

6. Jeffrey Tithof, Balachandra Suri, Ravi Kumar Pallantla, Roman O. Grigoriev, and Michael F. Schatz.  "Bifurcations in a quasi-two-dimensional Kolmogorov-like flow." J. Fluid Mech. 828 (2017): 837–866. [Link] [Movie]

5. Balachandra Suri*, Jeffrey Tithof*, Roman O. Grigoriev, and Michael F. Schatz.  "Forecasting Fluid Flows Using the Geometry of Turbulence." Phys. Rev. Lett. 118 (2017): 114501.  *Denotes equal contribution. Selected as an Editors' Suggestion. [Link] [Movie 1, Movie 2]

4. Miroslav Kramar, Rachel Levanger, Jeffrey Tithof, Balachandra Suri, Mu Xu, Mark Paul, Michael F. Schatz, and Konstantin Mischaikow. "Analysis of Kolmogorov Flow and Rayleigh-Bénard Convection using Persistent Homology."  Physica D 334 (2016): 82. [Link]

3. Balachandra Suri, Jeffrey Tithof, Radford Mitchell, Jr., Roman O. Grigoriev, and Michael F. Schatz.  "Velocity profile in a two-layer Kolmogorov-like flow." Phys. Fluids 26.5 (2014): 053601. [Link]

2. T. Papenbrock, Z. Pluhar, J. Tithof, and H. A. Weidenmüller.  "Chaos in fermionic many-body systems and the metal-insulator transition." Phys. Rev. E 83.3 (2011): 031130. [Link]

1. Yuri Kamyshkov, Jeffrey Tithof, and Mikhail Vysotsky.  "Bounds on new light particles from high-energy and very small momentum transfer np elastic scattering data."  Phys. Rev. D 78 (2008): 114029. [Link]

Dissertations / Theses

Jacob Stein. "Net Flow Through Soft Porous Media Generated by a Periodic Mean-Zero Pressure Gradient." University of Minnesota, Minneapolis, 2023. [Link]

Jeffrey Tithof. "Novel Methods of Dimensionality Reduction Applied to a Two-Dimensional Fluid Flow." Georgia Institute of Technology, Atlanta, 2016. [Link]