Jeff and collaborator Joseph Sushil Rao will give a Cassyni Seminar titled "Simulating Liver Resections to Predict Hepatic Perfusion Alterations," based on our recent J. Roy. Soc. Interface publication. Attend live on 4/17 at 9 am central!

Amit will be presenting a poster about his research at the Spring Undergraduate Research Symposium on 4/18 from 11:15 to 12:30.

Lily will be presenting a poster about her research at the MSI Research Computing Exhibition on 4/23 from 11:00 to 4:00.

March 2024

The APS March Meeting was held in Minneapolis from 3/3 to 3/8. Reza, Lily, Cooper, Mahsa, Himanshi, and Danny all gave excellent talks! Jeff also chaired the session "Physics of Neural Systems II" and former postdoc Saikat Mukherjee (now faculty at Iowa State University) presented some of our collaborative, ongoing work.

February 2024

Dorothea was admitted to the McNair Scholars Program and will be conducting research with us over the summer. Congratulations, Dorothea!

January 2024

Reza was awarded the UMN Interdisciplinary Doctoral Fellowship – congratulations, Reza! He received this competitive fellowship for his ongoing research developing Lattice Boltzmann simulations of solute transport in the brain. For this project, we've recently begun collaborating with Greg Handy in the School of Mathematics, who we got in contact with via our mutual membership in the Center for Neuroengineering. You can read more here!

December 2023

A big congratulations to Cooper, who was just selected for the University of Minnesota DSI-MnDRIVE Graduate Assistantship Award! This fellowship will support Cooper while he continues performing in vivo measurements of CSF flow through the brain.

Edith successfully defended her Master's, titled "Lumped Parameter Modeling of Changes in Liver Hemodynamics due to Cirrhosis"! She will begin working as a Thermal Systems Engineer at Trane Technologies in January. Congrats, Edith!

November 2023

Our coauthored study about how glymphatic and lymphatic fluid transport is inhibited following traumatic brain injury was published in Nature! We also show that a certain drug cocktail can be used to restore flow, leading to improved cognitive, behavioral, and motor function. Read the article here and a URMC news article here.

October 2023

Anika Volker, Silas Simpson, Thomas Ruhl, and Turki Saleh joined the lab to assist Cooper with in vivo CSF measurements in mice. We're glad to recruit some neuroscience majors to join us in research!

Hayat Ahmed joined the lab to work on improving particle tracking velocimetry. Welcome, Hayat!

Our paper "Lumped parameter liver simulation to predict acute hemodynamic alterations following partial resections" was published in Journal of the Royal Society Interface. Read it here!

September 2023

Jeff gave a seminar for the UMN Center for Neural Engineering titled "Cerebrospinal fluid flow: Opportunities for novel prevention and treatment strategies for neurodegenerative diseases."

Jeff shared his "Career Story" as part of a trainee day arranged by Doug Kelley, Maiken Nedergaard, Laura Lewis, and Patrick Drew. It was a pleasure chatting with all the grad students and postdocs!

August 2023

Dorothea Tse, a neuroscience major, joined the lab to assist Cooper with in vivo CSF measurement experiments. Welcome, Dorothea!

July 2023

Our paper "Quantifying the relationship between spreading depolarization and perivascular cerebrospinal fluid flow" was published in Scientific Reports! Congrats Saikat and Mahsa on an excellent computational study. Read it here.

Jeff gave a virtual seminar for the Mechanical and Mechatronics Engineering department at University of Waterloo. Thanks to Zhao Pan for the invitation!

June 2023

Saikat Mukherjee is moving on to a faculty position in Mechanical Engineering at Iowa State University. Congrats Professor Mukherjee! Check out the latest from his research group here.

May 2023

Jeff gave a seminar at the UMN Center for Magnetic Resonance Research titled "In Vivo Measurements of Cerebrospinal Fluid Flow: Novel Insights into Neurological Disorders." Thank you Cheryl Olman for the invitation!

April 2023

Jake Stein successfully defended his MSME Thesis! Jake is the first Master's student to graduate from the lab. Congrats on an excellent thesis characterizing fluid flow through soft porous media! Read it here.

January 2023

Jeff gave a seminar in the UMN Department of Surgery (Division of Transplantation) titled "Simulating Liver Resections for Pre-Operative Planning in Living Donor Liver Transplant."

Edith Joseph has joined the lab! For her Master's thesis, she will further develop our hydraulic network model of hepatic blood flow to simulate liver cirrhosis. Welcome, Edith!

Saikat has accepted an offer to join the Department of Mechanical Engineering at Iowa State University as an Assistant Professor beginning July 2023! A big congratulations!

December 2022

Minnesota Supercomputing Institute (MSI) covered our PNAS biofilms study in a recent Research Spotlight. Saikat used MSI resources for the simulations we performed in this study. Read the story here.

Jeff gave a 30-min talk at the Oslo Glymphatics Symposium titled "Glymphatics simulations under different parametric scenarios: Insight for future experiments." It was great to meet so many researchers from Norway and beyond doing cutting edge research -- and Oslo is a fantastic city! Thanks to Laura Bojarskaite and Vegard Vinje for the invitation and organizing the symposium.

November 2022

Jeff, Danny, Jake, Himanshi, Cooper, Saikat, Reza, and Lily each gave a 10-min contributed talk at the APS DFD conference in Indianapolis. We came back with lots of new ideas, and we met a few potential future collaborators! 

Tithof Lab APS DFD 2022

September 2022

Our recent study published in PNAS was highlighted by Burroughs Wellcome Fund! Read the article here: CASI Awardees Investigate Nature's Smallest "Social Cheaters"

Our collaborator, Dr. Joseph Sushil Rao, was recognized for his outstanding contributions to research! Read more here.

Congratulations to Saikat, who received an Honorable Mention for Impactful Research from the UMN Postdoctoral Association!

July 2022

Yale News reported on our recent PNAS article (link).

June 2022

"Social evolution of shared biofilm matrix components" was published in Proceedings of the National Academy of Sciences! This was an excellent collaborative work with Benny Tai and Jing Yan (Yale), as well as others.

Jeff and Saikat presented posters at the 11th Barriers of the CNS Gordon Research Conference.

Saikat presented our modeling research on spreading depolarization at the 8th European Conference on Computational Methods in Applied Sciences and Engineering (ECCOMAS) held in Oslo, Norway (link).

May 2022

Congratulations to Lindsay who graduated this semester!

March 2022

Lily Watkins joined the group! Lily will be co-advised by Saikat and she'll be working on a follow-up study to our recent Phys. Rev. E. paper. Welcome, Lily!

February 2022

Our article "Model of glymphatic clearance of aggregating proteins from the brain interstitium" was published in Physical Review E. Nice work, Saikat!

January 2022

Will Gustafson joined our lab! Will is interested in hydraulic network models, so he'll likely help develop simulations of CSF flow through the brain and/or blood flow through the liver.

Reza Yousofvand has joined the team! Reza will be developing simulations of flow through porous media using the Lattice Boltzmann Method. These simulations will offer an insightful complement to the experiments we've recently gotten up and running.

Jeff gave an invited talk and Himanshi presented a poster at (virtual) Dynamics Days 2022.

November 2021

Cooper Gray joined the team! Cooper will be working on mouse experiments in collaboration with Professor Kodandaramaiah's lab. Exciting things to come!

Danny, Jake, Mahsa, Nick, and Saikat all gave excellent talks at the APS Division of Fluid Dynamics Conference in Phoenix, AZ! Jeff also coauthored a great talk by Kimberly Boster (University of Rochester). Nice work, team!

October 2021

Lindsay Stiegler joined the lab! Lindsay is an honors student in Mechanical Engineering and will be writing her honors thesis about particle tracking. Welcome, Lindsay!

Jeff participated and presented at "The Glymphatic System: From Theoretical Models to Clinical Applications" in Copenhagen, Denmark. The meeting was exciting, informative, and inspiring. Jeff and other speakers at the workshop will be writing a consensus paper in the coming weeks. Stay tuned...

August 2021

Jeff presented at the (virtual) International Congress of Theoretical and Applied Mechanics (ICTAM 2020+1).

May 2021

Jeff has officially joined the Institute for Engineering in Medicine at UMN.

Himanshi Saini joins the team! Welcome, Himanshi!

Congratulations to Nick Conlin and Bharath Sivaram who graduated this semester!

March 2021

"Bulk flow of cerebrospinal fluid observed in periarterial spaces is not an artifact of injection" was published in eLife (link). 

February 2021

Our article "Dispersion as a waste-clearance mechanism in flow through penetrating perivascular spaces in the brain" was published in Scientific Reports (link).

January 2021

Chinmayee Panigrahi and Jake Stein have joined the lab to work on porous media experiments. Welcome Jake and Chinmayee – let's fire up the particle tracking!

November 2020

Daehyun "Danny" Kim has joined the lab. Welcome to the team, Danny!

Saikat's research and presentation at the APS DFD conference were highlighted in the press release Tracing the Flow of Cerebrospinal Fluid. Excellent work, Saikat!

Jeff, Saikat, and Mahsa presented at the American Physical Society Division of Fluid Dynamics virtual conference.

Saikat gave a talk about his research in the ME Connect seminar series.

October 2020

Mahsa also gave a talk about her research in the ME Connect seminar series.

Mahsa presented her research in the departmental 3 Minute Thesis competition, which challenges grad students to summarize their research in an engaging and understandable way, in under three minutes. Watch her video here. Great concise summary, Mahsa!

September 2020

Saikat and Mahsa both gave poster presentations at the UMN Institute for Engineering in Medicine Annual Conference. The conversation was intriguing! Check out the program here.

Bharath Sivaram has joined the team to work on a variety of research projects and help set up the lab. We're glad to have your help, Bharath!

August 2020

Nick Conlin has started collaborating with our team. Nick is an AEM major completing an undergraduate thesis focused on 2D flows and is coadvised by Jeff and Professor Maziar Hemati. Welcome, Nick!

July 2020

Saikat Mukherjee has joined the team to conduct research on multiple topics, including spreading depolarization in the brain. We’re glad to have you join us, Saikat!

June 2020

Jeff has officially started as an assistant professor at University of Minnesota!

January 2020

Mahsa Mirzaee has joined the team to work on simulations of cerebrospinal fluid flowing through perivascular spaces in the brain. Welcome, Mahsa!